Is PRP Really Better Than Hyaluronic Acid for Knee Osteoarthritis?
New Research Says Yes.
If you’ve been living with knee pain from osteoarthritis, chances are you’ve heard of both hyaluronic acid (HA) and platelet-rich plasma (PRP) injections. These two treatments are often used to relieve discomfort and improve mobility, but which one actually works better?
A new meta-analysis published in Arthroscopy (2025) offers clear insight—and the findings strongly favor PRP.
Understanding the Treatments: HA vs. PRP
- Hyaluronic Acid (HA) is a gel-like substance that mimics the natural fluid in your joints. It helps cushion and lubricate the knee.
- Platelet-Rich Plasma (PRP) is made from your own blood. It’s rich in growth factors that can reduce inflammation and promote healing in the joint.
Both are injected directly into the knee joint and are popular nonsurgical options for those trying to delay or avoid knee replacement surgery.
What Did the Study Find?
Researchers analyzed 15 double-blind randomized trials comparing PRP and HA for treating mild to moderate knee osteoarthritis.
- Pain Relief: PRP significantly outperformed HA in reducing pain scores at 12 months.
- Function Improvement: PRP led to greater gains in joint function and quality of life.
- Faster Benefits: Some improvements were noticeable as early as 1 month post-injection with PRP.
The difference in relief was clinically meaningful—not just statistically significant.
What This Means for You as a Patient
At OC Sports and Wellness, we specialize in integrative, evidence-based therapies that help active adults and athletes return to the activities they love. This study reaffirms what we’ve seen in practice:
PRP is a more effective long-term solution than HA for many patients with knee osteoarthritis.
While HA may still have a place, this research suggests that PRP offers stronger, longer-lasting pain relief and improved function.
Why Does PRP Work So Well?
PRP stimulates the body’s natural healing mechanisms:
- Decreases joint inflammation
- Promotes cartilage repair
- Enhances tissue regeneration
- Improves joint lubrication
Since it’s made from your own blood, it’s also biocompatible and has a low risk of allergic reaction or rejection.
PRP vs. HA at a Glance
| Feature | PRP | HA |
|---|---|---|
| Source | Your own blood | Synthetic or animal-based |
| Goal | Heal + reduce inflammation | Lubricate + cushion |
| Duration of Relief | Up to 12 months (or more) | Typically 3–6 months |
| Ideal For | Mild to moderate OA | Early-stage OA |
| Side Effects | Mild swelling, temporary | Very few, similar profile |
Is PRP Right for You?
If you:
- Have persistent knee pain from osteoarthritis
- Want to avoid or delay joint replacement surgery
- Are looking for a natural, regenerative solution
…then PRP may be your best next step.
What to Expect at OC Sports and Wellness
Our PRP therapy process is personalized, precise, and evidence-based:
- Consultation & imaging to confirm your diagnosis
- Customized PRP preparation from your own blood
- Ultrasound-guided injection to ensure accuracy
- Follow-up care to monitor healing and mobility
As one of the few clinics in Orange County to also offer Prolozone Therapy and Stem Cell Therapy, we can combine regenerative treatments to enhance your recovery.
Ready to Move Without Pain?
This study provides strong confirmation that PRP is effective—and that it is more effective than hyaluronic acid for many patients with knee osteoarthritis.
Contact us to schedule your consultation and discover if PRP is the proper treatment for you.
Reference:
Li B, et al. Platelet-Rich Plasma Is More Effective Than Hyaluronic Acid Injections for Osteoarthritis of the Knee: A Meta‑Analysis Based on Randomized, Double‑blinded, Controlled Clinical Trials. Arthroscopy. 2025. View Abstract
We hope this information is helpful. At OC Sports and Wellness in Orange County, we understand the importance of balancing your health with a busy lifestyle. That’s why we offer convenient options for scheduling visits, texting, or video chatting with Dr. Sunshine. Let’s work together towards your well-being! Please feel free to contact us at 949-460-9111.
Our sports medicine practice is within driving range of Aliso Viejo, Anaheim, Brea, Buena Park, City of Orange, Costa Mesa, Cypress, Dana Point, Fountain Valley, Fullerton, Garden Grove, Huntington Beach, Irvine Sports Medicine, La Habra, La Palma, Laguna Beach, Laguna Hills, Laguna Niguel, Laguna Woods, Lake Forest, Los Alamitos, Mission Viejo, Newport Beach, Placentia, Rancho Santa Margarita, San Clemente, San Juan Capistrano, Santa Ana, Seal Beach, Stanton, Tustin, Villa Park, Westminster, and Yorba Linda. We look forward to seeing you soon!
